Russia's Soyuz TMA-22 spacecraft with three astronauts onboard blasted off from the Baikonur space center in Kazakhstan on Monday, according to Russia's Federal Space Agency Roscosmos.
The new crew to the International Space Station (ISS) consists of Anton Shkaplerov and Anatoli Ivanishin from Russia and Daniel Burbank from the United States.
The launch, which was conducted as planned at 08:14 Moscow time (0414 GMT), has been delayed for almost two months after a Progress cargo craft crash in August.
The spacecraft would send the new members to join Russian cosmonaut Sergei Volkov, Japanese Space Agency astronaut Satoshi Furukawa and NASA astronaut Michael Fossum, who have been working in orbit since early June.