puzzle

 ACROSS

  1 No-win situations?

  5 Respectful address

  9 Bar bill

 12 Address the U.N. assembly, say

 13 Color of honey or mirin

 15 Magenta or mustard

 16 Red ingredient in meatloaf (In this answer, note the first letter + the last 4)

 18 Green card and others

 19 "OK, ___ bite"

 20 Feels unwell

 21 Opposite of sketchy

 23 Insomniac's frustration (first letter + last 4)

 27 Dull color

 28 Its shell is edible

 29 Take an oath

 31 Teri of "Mr. Mom"

 33 Cries uncontrollably

 37 F-, e.g., in chemistry class

 38 Excessive (first 2 letters + last 3)

 41 Zodiac lion

 42 Musician Rundgren

 44 Pound or foot

 45 Drew to a close

 47 "Assuming that's true ..."

 49 Not yet eliminated

 50 Very sad (first 4 letters + last 3)

 56 Jiggly dessert

 57 Per person

 58 "Me?!"

 59 "___ you sure?"

 60 He played a shape-shifter in "True Blood" (first letter + last 4)

 64 Seven Dwarfs' leader

 65 Rosebush hazard

 66 Major artery

 67 M.D. treating laryngitis

 68 "Cornflake Girl" singer Tori

 69 Rudolph's is red


DOWN

  1 Reddit provocateur

  2 2007 thriller about the last human in New York City

  3 Flight tracker stat

  4 Differentiate

  5 Syrup source

  6 Accumulate

  7 Crunches work them

  8 Got acquainted with

  9 Piece of chicken

 10 Tax cheat's dread

 11 Top-of-the-line

 12 Elevator brand

 14 The Shroud of Turin, e.g.

 17 Like trout or tuna

 22 Big stars have big ones

 24 Period of history

 25 Walk on the runway

 26 Weed-seizing cop

 29 Rest on a meditation cushion

 30 Pursue romantically

 31 "Leave this instant!"

 32 "Why ___ not surprised?"

 34 Many loyal employees

 35 Busy worker in the garden?

 36 Lawn roll

 39 Remove from office

 40 Guy who assists a villain

 43 Clock face

 46 Medical research org.

 48 Fall pumpkin coating

 49 Machu Picchu builder

 50 Bird with an S-shaped neck

 51 Choose by voting

 52 Like a throwback style

 53 Deserves

 54 Nick of "Warrior"

 55 ___ monster (venomous lizard)

 56 Facial roller gemstone, often

 61 "I solved it!"

 62 May 8, 2022, VIP

 63 Sound from a steer

solution