Britain's Foreign Secretary Liz Truss and US Secretary of State Antony Blinken attend a G7 Foreign and Development Ministers Session with Guest Countries and ASEAN Nations in Liverpool, north-west England on December 12, 2021. Photo: AFP

UK Foreign Secretary Liz Truss on Thursday hosts her first face-to-face meeting with European Commission vice president Maros Sefcovic, aiming to break months of deadlock over post-Brexit trade in Northern Ireland.

Truss, who was appointed to take over from Brexit minister David Frost after his resignation in December 2021, will welcome Sefcovic at her official country residence, Chevening, in southeast England.

Before the talks, she said: "There is a deal to be done that protects peace in Northern Ireland, defends our Union, and maintains the integrity of the United Kingdom and European Union.

"But it will require a pragmatic approach from the EU."

Northern Ireland, which has the UK's only land border with the European Union, has been a major stumbling block in the entire Brexit process since the vote to leave the bloc in a 2016 referendum.

The Northern Ireland Protocol was signed separately from the wider Brexit trade deal between the UK and the EU and aims to avoid a "hard" border on the island of Ireland.

But to keep the border open - a key plank of a 1998 peace agreement that ended decades of violence over British rule in Northern Ireland - the province is effectively still in the European single market.

Checks are required for goods heading east-west from mainland Great Britain (England, Scotland and Wales) to stop unchecked products heading into the single market via Northern Ireland.

But London has indefinitely suspended implementing those checks, and wants the protocol renegotiated, including the removal of European judicial oversight on disputes. 

Brussels has rejected the UK call for the European Court of Justice to be replaced with an international arbitration panel.

Frost in December cautiously welcomed the Commission's proposal to reform EU medicine supply rules but poured cold water on hopes that an overall agreement to end the row had been found. 

A solution needed to be found "urgently early next year," he said, warning that the UK was "ready to use the Article 16 safeguard mechanism" if necessary, referring to the suspension clause in the agreement.

Truss, who took over from Frost after his resignation, said she was also prepared to trigger that clause, which the EU has warned could lead to a wider trade war.

Last weekend, EU ambassador to the UK Joao Vale de Almeida, called Truss's threat unhelpful. 

"We've heard this before from the government, so we're not surprised. We are not too impressed," he said.

"We still believe it's not very helpful that we keep agitating the issue of Article 16.